SGC-CBP30
- Product Name
- SGC-CBP30
- CAS No.
- 1613695-14-9
- Chemical Name
- SGC-CBP30
- Synonyms
- CS-993;SGCBP30;CS-1923;SGC-CBP30;SGCBP30;SGCCBP 30;SGCCBP30;SGC CBP30;SGC-CBP30 USP/EP/BP;(S)-4-(1-(2-(3-Chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-;2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole;1H-Benzimidazole, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-
- CBNumber
- CB52670792
- Molecular Formula
- C28H33ClN4O3
- Formula Weight
- 509.04
- MOL File
- 1613695-14-9.mol
SGC-CBP30 Property
- Boiling point:
- 678.0±55.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≥20.05 mg/mL in DMSO; ≥25.7 mg/mL in EtOH with ultrasonic; ≥4.67 mg/mL in H2O with ultrasonic
- form
- powder
- pka
- 6.98±0.10(Predicted)
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1133
- Product name
- SGC-CBP30
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- SML1133
- Product name
- SGC-CBP30
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $634
- Updated
- 2024/03/01
- Product number
- 14469
- Product name
- SGC-CBP30
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 14469
- Product name
- SGC-CBP30
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 14469
- Product name
- SGC-CBP30
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $812
- Updated
- 2024/03/01
SGC-CBP30 Chemical Properties,Usage,Production
Description
SGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor. SGC-CBP30 shows Kd values are 21 and 32 nM for CBP and p300 BRDs respectively. SGC-CBP30 also exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. SGC-CBP30 accelerates FRAP recovery in cells at a concentration of 1 ?M.
Uses
SGC-CBP30 is a potent CREBBP/EP300 inhibitor.
Biochem/physiol Actions
SGC-CBP30 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.021 and 0.038 μM, respectively). SGC-CBP30 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please visit the SGC-CBP30 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
target
CREBBP
storage
Store at +4°C
SGC-CBP30 Preparation Products And Raw materials
Raw materials
Preparation Products
SGC-CBP30 Suppliers
View Lastest Price from SGC-CBP30 manufacturers
- Product
- SGC-CBP30 1613695-14-9
- Price
- US $9.80-8.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99.99%
- Supply Ability
- 10 MT/ Month
- Release date
- 2020-10-28